Cardiovascular system
The cardiac conduction system is affected by magnesium in several ways. Hypomagnesemia is more common in patients with heart failure, most likely due to the use of diuretics. Non-potassium-sparing diuretics lower potassium and magnesium levels in the blood and the body as a whole. Low magnesium and potassium levels increase the risk of ventricular ectopic activity, leading to arrhythmic death. Mg depletion was not found to be an independent risk factor for death in a large prospective analysis, despite other studies finding a link between cardiovascular mortality and low levels of blood Mg (Hansen
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