Order The endothelial Cell Discussion

Order The endothelial Cell Discussion
Order 5983849
Order The endothelial Cell Discussion
9.1 Endothelial cells
a. line the entire cardiovascular system, except the cardiac chambers.
b. are usually joined together by continuous, unbroken junctional strands
of protein.
c. can communicate through electrically conductive gap junctions.
d. have a semipermeable coat of biopolymers on the luminal surface.
e. resist the shearing force of blood through β1 integrin-collagen bonds.
9.2 Endothelial cells express
a. K channels that contribute to a negative intracellular membrane potential.
b. Ca2-conducting channels that close in response to inflammatory mediators.
c. Ca2-conducting channels activated by Ca2 store depletion.
d. Ca2-activated potassium channels that depolarize the cell.
e. an enzyme that is activated via a rise in cytosolic Ca2 and catalyses the
production of a vasodilator agent.
Order The Endothelial Cell Discussion
9.3 Endothelium-generated nitric oxide (NO)
a. is produced continuously from citrulline.
b. is a circulating hormone that induces widespread vasodilatation.
c. induces vasodilatation by raising intracellular cAMP in vascular smooth
muscle.
d. is produced tonically in response to the shear stress of flowing blood.
e. contributes to the characteristic heat and redness of inflammation.
For a change, here is a different style of question.
Order The Endothelial Cell Discussion
9.4 Factors produced by endothelium.
Endothelial cells produce many biologically active agents.The well known vasodilator gas
__________ is also an inhibitor of __________ and __________, so it has an __________
action.The identity of another endothelium-dependent vasodilator, called __________, is
controversial. Endothelium also secretes a derivative of arachidonic acid, __________, which
inhibits __________ and __________. In addition, endothelium secretes a peptide related
to snake venom, called __________, that causes long-lasting __________. Lung endothelium
possess a surface peptide-degrading enzyme that generates the circulating hormone
__________, another agent that causes __________. Not all endothelial secretions are
vasoactive, however. For example, a glycoprotein involved in the clotting cascade, called
__________, is secreted continuously, and is also stored inside endothelium in a structure
called a __________.
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