The intercellular splitting of the MurNAc-6P-GlcNAc by novel phospho-glycosidase brings about the first representative of novel phospho-muramidase enzymes. Most of the cell wall lytic enzymes have undergone the “mix and match” approach, which brings together the functions of various cleavage catalytic functions. Vincent et al. show how horizontal gene transfers create a mycobacterial cell wall after running a hypothesis of the evolutionary origins of this cell wall (Drr et al., 2019). The research ends by concluding that the arabinogalactan components predate the outer membrane and the virulence-related lipids.
The sensing of the bacterial PG molecules shows that there is a lot to be researched and learned. Identifying the novel PG receptors will need more work because the field cannot avoid developing and applying new analytical techniques. Recycling of peptidoglycan, degradation, and recovery are the only ways the Gram-positive bacteria can be achieved.
Bacterial cell wall biology is one of the most significant frontiers in discovering novel components and developing a profound understanding of basic microbiology. This is essential in finding treatment for drug-resistant bacterial infections.
Reference
Drr, T., Moynihan, P. J.,
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